Vitamin B-12 White paper
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When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide** Not only has methylcobalamin been shown to work in neurologic diseases,(diabetic neuropathy) it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalamin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanide and depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
| “These findings indicate that methyl-B12 promotes regeneration of degenerating nerve terminals” Says scientist K Yamazaki – 1994 |
| “An overall beneficial therapeutic effect on the neuropathy status was observed in all three groups during the study, and a significant improvement in most of the parameters studied appeared already at the 3rd week of therapy. The greatest change occurred in the group of patients receiving the high dose of benfotiamine” Says researcher G Winkler – 1999 |
| “Ultra-high dose methylcobalamine promotes nerve regeneration.” Scientist T Watanabe – 1994 |
| “The active group showed statistical improvement… and no side effects were encountered.” Researchers from King Khalid University |
| “The active group showed statistical improvement in the somatic and autonomic symptoms with regression of signs of diabetic neuropathy. The drug was easily tolerated by the patients and no side effects were encountered.” Scientist R Sulimani – 1992 |
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Dr.Thomas Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
MAXN*FUZE uses Cynacobalamin which has been found to be slightly toxic due the the cyanide .
Buy transdermal Patches without a prescription.
When talking about vitamin B12, this is actually a generic term for a class of compounds called the Cobalamins, and indeed when one has vitamin B12 deficiency, it is more scientifically called Cobalamin Deficiency. This makes perfect sense when you understand that the various formulations of Vitamin B12 all end with the suffix Cobalamin. While there are MANY `Cobalamins`, only three are generally used as dietary supplements, namely: Hydroxocobalamin Cyanocobalamin Methylcobalamin All three types are considered `Vitamin B12`, they are NOT all the same and using the right one can be a critical decision. Cyanocobalamin is probably the most commonly used in the medical world and is often given as `B12 Shots` in a doctor's office for those with certain medical conditions. But cyanocobalamin is actually the WORST choice, despite the fact that doctors in the US are more likely to prescribe it over any other form. Not only does cyanocobalamin require a higher dosage for the same effectiveness of hydroxycobalamin, but it is Entirely Ineffective for several different conditions related to vitamin B12 deficiency. As such, it has been suggested repeatedly by several researchers, starting with Dr. AG Freeman in 1970, that cyanocobalamin should be removed from the market. While Great Britain followed through with researcher recommendations and removed the inferior product, doctors in the the United States have no such restrictions and still use cyanocobalamin routinely. "...there [is] no condition in which it has been claimed that cyanocobalamin was preferable to "Methylcobalamin" `Cyanocobalamin- a case for withdrawal: discussion paper` While hydroxocobalamin is preferred over cyanocobalamin, another formulation called Methylcobalamin is actually the BEST choice. Technically a `coenzyme` of vitamin B12, it is almost never used despite being effective, readily available, inexpensive and available in both sublingual preparations and injectable form. This is too bad because there are many people that could very well benefit from the methylcobalamin form of vitamin B12 that would NOT benefit from the other forms. Degenerative neurologic problems are where methylcobalamin shows its greatest benefits over other cobalamin preparations, and it is often one of the ONLY promising treatments for these tragic diseases. While Japan uses methylcobalamin nearly exclusively and it is the form present in prescription vitamin B12 there, the United States has virtually ignored the hundreds of studies that show the benefits this simple vitamin can bring. "Methylcobalamin is the form found in food and has much higher bioavailability than the form most widely available in supplements, cyanocobalamin." `B12 (Cobalamin)` As Wikipedia explains: "A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide... Not only has methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body. One of the ways that humans detoxify is through a process called 'Methylation'. Methylation is a CRITICAL function of a healthy body, but all too often we 'use up' the necessary raw materials because of our nearly constant exposure to environmental pollutants. Methylcobalamin is actually able to replenish the 'methyl' portion that is missing in methylation, while the other forms of vitamin B12 REQUIRE a methyl donor in order to be converted into a biologically active form in the blood. Therefore, people who already HAVE methylation detoxification problems, such as children with autism, and Asperger's can actually be made WORSE if other forms of vitamin B12 are administered! While getting ENOUGH vitamin B12 is an important factor for maintaining general well being, getting the right KIND, in the form of methylcobalin is equally important. In fact, choosing correctly could very well mean the difference between good health and disease. **Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called "methyl groups" of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low-quality cyanobalamin, you're actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. |
In summary the slightly toxic form of b-12 known as cyanobalamin uses cyanideand depletes the vital methyl groups forcing a heavy load on the master molecule glutathione. Glutathione is critical for fighting free radicals and anti-oxidation.
References
[1] McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total seru m homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13(4):235-239.
[2] Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55(11):1449-55.
[3] Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103(2):149-57.
[4] Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4):301-7.
[5] Baig SM, Qureshi GA. Homocysteine and vitamin B12 in multiple sclerosis. Biogenic Amines 1995;11(6):479-485.
[6] Hoffer LJ, Bank I, Hongsprabhas P, Shrier I, Saboohi F, Davidman M, Bercovitch DD, Barre PE. A tale of two homocysteines--and two hemodialysis units. Metabolism 2000;49(2):215-9
[7] D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L, Cerbone AM. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83(4):563-70.
[8] Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol 1993;241(1):1-6.
[9] Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38(5):848-54.
[10] Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
[11] Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
[12] Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.
[13] Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 1999;38(6):472-5.
[14] Pezacka E, Green R, Jacobsen DW. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 1990;169(2):443-50.
[15] Turley CP, Brewster MA. Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. J Nutr 1993;123(7):1305-12.
[16] Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37(4):173-182.
[17] Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44(3):169-73.
[18] Choi SW. Vitamin B12 deficiency: a new risk factor for breast cancer? Nutr Rev 1999; 57(8):250-253.
Tom Hiatt
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